科学与数学allthatsinteresting.com
肯塔基 Fugate 家族：蓝皮肤延续数代
The Fugate family of Kentucky has had blue skin for centuries
2019 — 2021，它一次次回到首页
黑点是上首页（≥ 50 分）的那次投稿，空心点是没冲上去的投稿，点越大分数越高。
导读
这篇文章讲述了肯塔基州的富盖特家族：由于近亲通婚和一种隐性基因导致的高铁血红蛋白血症，这个家族的成员几个世纪以来皮肤呈蓝色。文章介绍了这种遗传病的成因、家族历史，以及后来通过亚甲基蓝染料治疗使肤色恢复正常的故事。
为什么经久不衰：它把一段离奇的家族史与真实的遗传学知识结合在一起，既满足好奇心又能学到隐性基因和隔离人群在遗传研究中的作用，因此多年来反复引发讨论。
HN 评论精选
遗憾文章缺少真实的彩色照片佐证
文章很精彩，但有点让人沮丧的是没有彩色照片。我试着在网上搜索，找到了其他蓝皮肤人的照片，但他们的病因都不是这种基因（大多是银中毒）。
mkl查看英文原文
A fascinating article, but it's a bit frustrating that there are no colour photos. I tried searching the internet and found photos of other blue-skinned people but none of them had this genetic cause (mostly it was silver "supplements").
上色照片不可靠，且文章疑似抄袭
用一张不知由谁、不知何时上色的黑白照片来配一篇讲颜色的文章，有点不诚实——照片唯一有趣的信息（蓝色的深浅）恰恰没有来源。另外这篇文章似乎大量抄袭了 ABC News 的报道。
hk__2查看英文原文
> The Blue Fugates are shown in this colorized black and white photo. Date unspecified. Original source unknown, via ABC News It’s somewhat dishonest to illustrate an article on color with a photo that was colorized by someone we don’t know at an unknow date-- i.e. we don’t know anything about how they decided which shade of blue to apply on their faces. So the only interesting information caried by the photo, the shade of the blue color, has no source. Also, this appears to be largely copied from this ABC News article: https://abcnews.go.com/Health/blue-skinned-people-kentucky-reveal-todays-genetic-lesson/story?id=15759819
隔离人群是研究隐性遗传病的关键
这篇文章触及了一个至今仍然成立的道理：想研究遗传病，就要研究高度近亲繁殖的群体。如果所研究的疾病与隐性基因相关，你需要一个携带该基因的隔离人群。在动植物育种中，近亲繁殖同样有用：通过近交让隐性基因表达出来，从而确定哪些亲本系携带该基因。
sandworm101查看英文原文
This article touches on something that remains very true today: if you want to study genetic disorders you look at closely-related populations. If the condition you want to study is linked to a recessive gene, you want to find (or create) an isolated population with that gene. In animals/plants this is why inbreeding can serve a useful function. If you want to detect a recessive gene, but either don't have access to genetic testing or are not sure which gene is involved, you in-breed until you see individuals who express the recessive gene. These individuals inherited the recessive gene from both parents. You then know which parental lines carry the gene, which lets you select for or against it.
亚甲基蓝疗法的发现令人惊叹
亚甲基蓝染料能治疗这种病的发现非常有趣。这么罕见的病，到底是怎么发现疗法的？想象一下一辈子都是深蓝色、人人都叫你'蓝人'，然后吃了这种蓝色药丸，一下子变得粉红——简直像实用的魔法。
dougmwne查看英文原文
The discovery of the treatment in the methylene blue dye is quite fascinating. How exactly did someone figure that out for such a rare condition? And imagine being deep blue all your life and everyone knowing you as blue, then you take this blue pill and bam, you're pink as can be. Must have seemed like practical magic.
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